校長室

校長.李文華 講座教授副校長.陳偉德 教授 ∣副校長.吳永昌 教授 副校長.林正介 教授副校長.蔡輔仁 教授

副校長 吳永昌 教授

副校長 吳永昌 教授

副校長 吳永昌 教授

聯絡資訊

  1. 電話:886-4-22053366分機1012
  2. 傳真:886-4-22060248
  3. 電子信箱: yachwu@mail.cmu.edu.tw
  4. 秘書:殷夢婷 小姐

英文簡歷

View English CV

學歷

年度 學歷
1987 美國北卡羅萊那大學藥學院 博士後研究員(李國雄院士實驗室)
1986-1987 日本名城大學 藥學部 博士後研究員(日本天皇賞平田義正教授實驗室)
1982-1987 高雄醫學大學 醫學研究所理學博士
1979-1982 高雄醫學大學 醫學研究所理學碩士
1971-1975 高雄醫學大學 藥學學士

經歷

年度 經歷
2004-2010 國立高雄大學 生命科學研究所 兼任教授
2007-2009 台灣藥學會 理事
2003-2005 行政院SARS專案研究計畫中醫藥學組 召集人
2003 行政院衛生署中華中藥典 編輯委員
2002迄今 經濟部工業局 協助傳統工業技術開發計劃 評審委員
2002-2009 中華民國中醫師公會全國聯合會 學術顧問
2002-2004 行政院國家科學委員會生物處藥學及中醫藥學門 召集人
1998-2009 財團法人製藥工業技術發展中心 中草藥推動小組 諮詢委員
1997-2001 高雄醫學大學 進修推廣部 主任
1996迄今 行政院衛生署中醫藥委員會 委員
1998-2002 財團法人國際醫學科學研究基金會 董事
1994迄今 考選部 典試委員
1994-1997 高雄醫學大學 學術及教育推廣中心 推廣教育組 主任
1993-2008 高雄醫學大學 教務處研教組 主任
1992-2006 中華天然藥物學會 理事
1992-2006 高雄醫學大學 天然藥物研究所 教授兼所長
1990迄今 國立中山大學 海洋資源研究所 兼任教授
1990-1992 高雄醫學大學 藥學系、藥學研究所 教授
1989-1992 高雄醫學大學 教務處註冊組 主任
1986-1990 高雄醫學大學 藥學系 副教授

現職

  1. 高雄醫學大學天然藥物研究所合聘教授
  2. 中國醫藥大學 中醫學院/中西醫結合研究所講座教授/副校長
  3. 國立中山大學 生物醫學研究所合聘教授
  4. 行政院衛生署 中醫藥委員會委員
  5. 台灣藥學會 常務理事
  6. 中華天然藥物學會 理事長

獎譽

年度 經歷
2000 財團法人永信李天德醫藥基金會「第五屆永信李天德卓越醫藥科技獎」
2008 高雄醫學大學學術類傑出校友
2008 國家科學委員會「傑出研究獎」
2007 財團法人王民寧先生紀念基金會『第十七屆王民寧醫藥研究傑出貢獻獎』
2000-2009 高雄醫學大學研究傑出教師獎
2002 天主教輔仁高級中學 傑出校友
2000 中華民國第一屆傑出中藥神農獎 奉獻獎
1999 教育部服務二等獎章
1992 教育部優良教師獎
1992、1993 國科會優等研究獎
1986-1990、1994-2000 國科會甲種獎助

參加學會

  1. 台灣 中華天然藥物學會
  2. 台灣 中國化學會
  3. 台灣 台灣藥學會
  4. 美國 美國生藥學會
  5. 美國 美洲華人生物科學學會
  6. 德國 歐洲藥用植物學會

期刊編輯委員

  1. Planta Medica (Germany)
  2. Marine Drugs (Swiss)
  3. The Chinese Pharmaceutical Journal (Taipei)
  4. Journal of Chinese Medicine (Taipei)
  5. Journal of Chinese Medicine (China)

期刊審稿委員

  1. Tetrahedron & Tetrahedron Letters (England)
  2. Journal of Natural Products (U.S.A)
  3. Phytochemistry (England)
  4. Phytomedicines (Germany)
  5. Journal of The Chinese Chemical Society (Taipei)
  6. Journal of Food and Drug Analysis (Taipei)
  7. Journal of the Chinese Chemical Society (Taipei)
  8. Journal of Agriculture and Food Chemistry (USA)
  9. Plant Biology (Germany)
  10. Planta Medica (Germany)
  11. European Journal of Medicinal Chemistry (France)
  12. Natural Product Research (Parkistan)


論文著述

Articles【2006-2011】
Yung-Husan Chen, Fang-Rong Chang, Chin-Chung Wu, Ming-Hon Yen, Chih-Chuang Liaw, Hui-Chi Huang, Shu-Li Chen, Yang-Chang Wu*, 2006, “New cytotoxic 6-oxygenated 8,9-dihydrofurocoumarins, hedyotiscone A-C, from Hedyotis bifloraPlanta Medica, 72, 75-78. (SCI)
Fang-Rong Chang, I-Hsiao Chen, Sin-Chung Liao, Hamad H. Issa, Ken-ichiro Hayashi, Hiroshi Nozaki, Yang-Chang Wu and Kuo-Hsiung Lee*, 2006, “Three new Agarofuran Sesquiterpenes reissantins F-H from Reissantia buchananiiPlanta Medica, 72, 92-96. (SCI)
Shyng-Shiou F. Yuan, Hsueh-Ling Chang, Hsiao-Wen Chen, Fu-Chen Kuo, Chih-Chuang Liaw, Jinu-Huang Su, Yang-Chang Wu*, 2006, “Selective cytotoxicity of squamocin on T24 bladder cancer cells at the S-phase via a Bax-, Bad-, and caspase-3-related pathways”, Life Sci., 78, 869-874. (SCI)
Mei-Chin Lu, Sheng-Huei Yang, Shiuh-Lin Hwang, Yu-Jhang Lu, Yi-Hsiung Lin, Sen-Ren Wang, Yang-Chang Wu*, Shinne-Ren Lin*, 2006, “Induction of G2/M phase arrest by squamocin in chronic myeloid leukemia (K562) cells”, Life Sci., 78, 2378-2383. (SCI)
Chih-Hua Chao, Chi-Hua Hsieh, Shin-Pin Chen, Chung-Kuang Lu, Chang-Feng Dai, Yang-Chang Wu, Jyh-Horng Sheu, 2006, “Novel cyclic sesquiterpene peroxides from the Formosan soft coral Sinularia sp.”, Tetrahedron Letters, 47, 2175-2178. (SCI)
Hui-Chi Huang, Wei-Jern Tsai, Susan L. Morris-Natschke, Harukuni Tokuda, Kuo-Hsiung Lee, Yang-Chang Wu*, and Yao-Haur Kuo*, 2006, “Sapinmusaponins F-J, Bioactive Yirucallane-Type Saponins from the Galls of Sapindus mukorossi”, J. Nat. Prod., 69, 763-767. (SCI)
Yu-Hsuan Lan, Fang-Rong Chang, Yu-Liang Yang, and Yang-Chang Wu*, 2006,“New Constituents from Stems of Goniothalamus amuyon”, Chem. Pharm. Bull., 54,1040-1043. (SCI)
Atallah F. Ahmed., Ming-Hsuan Wu, Yang-Chang Wu, Chang-Feng Dai, and Jyh-Horng Sheu, 2006, “Metabolites with Cytotoxic Activity from the Formosan Soft coral Cladiella australis.”, J. Chin. Chem. Soc.,53,489-494. (SCI)
Wen-Bin Pan, Li-Mei Wei, Li-Lan Wei, and Yang-Chang Wu*, 2006, “Chemical Constituents of Tupistra chinensis Rhizomes.”, Chem. Pharm. Bull., 54, 954-958. (SCI)
Ping-Jyun Sung, Yu-Pei Chen, Tsong-Long Hwang, Wan-Ping Hu, Lee-Shing fang, Yang-Chang Wu, Jan-Jung Li and Jyh-Horng Sheu, 2006, “Briaexcavatins C-F, four new briarane-related diterpenoids from the Formosan octocoral Briareum excavatum (Briareidae).”, Tetrahedron, 62, 5686-5691. (SCI)
Hsueh-Ling Chang, Hseng-Kuang Hsu, Jinu-Huang Su, Pei-Hui Wang, Yueh-Fang Chung, Yi-Chen Chia, Li-Yu Tsai, Yang-Chang Wu, Shyng-Shiou F. Yuan, 2006, “The fraction Toona sinensis leaf extract induces apoptosis of human ovarian cancer cells and inhibits tumor growth in a murine xenograft model”, Gynecol. Oncol., 102, 309-314. (SCI)
Hsu JH, Yang-Chang Wu, Liu IM, Cheng JT ,2006” Release of acetylcholine to raise insulin secretion in Wistar rats by oleanolic acid, one of the active principles contained in Cornus officinalis”, Neuroscience Letters, 404, 112-116. (SCI)
Jui-Hsin Su, Tseng YJ, Tsong-Long Hwang, Atallah F. Ahmed, Lu CK, Yang-Chang Wu, Jyh-Horng Sheu, 2006, “9,11-Secosterols from the soft corals Sinularia lochmodes and Sinularia leptoclados”, J. Nat. Prod., 69, 850-852. (SCI)
AF Ahmed, YT Hsieh, ZH Wen, Yang-Chang Wu, JH Sheu, 2006, “Polyoxygenated sterols from the formosan soft coral Sinularia” gibberosa.”, J. Nat. Prod.,69,1275-1279(SCI)
Wei-Ying Wang, Yang-Chang Wu, Chin-Chuang Wu*, 2006, “Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosine kinase inhibitor.”, Molecular Pharmacology, 70,1380-1389(SCI)
Yi-Chen Chia, Fang-Rong Chang, Chin-Chuang Wu, Che-Ming Teng, Keh-Shaw Chen,* and Yang-Chang Wu*, 2006, ” Effect of Isoquinoline Alkaloids of Different Structural Types on Antiplatelet Aggregation in Vitro”, Planta Medica, 72, 1238-1241 (SCI)
Fang-Rong Chang, Tsong-Long Hwang, Yu-Liang Yang, Chia-En Li, Chin-Chung Wu, Hamad H. Issa, Wen-Bin Hsieh, Yang-Chang Wu*, 2006, “Antiinflammatory and Cytotoxic Diterpenes from Formosan Polyalthia longifolia var. pendula ”, Planta Medica., 72, 1344-1347 (SCI)
Yaw-Bin Huang, Pao-Chu Wu, Chia-Shin Su, Yang-Chang Wu, Yi-Hung Tsai*, 2006 , “Simultaneous quantification of twelve bioactive components in San-Huang-Xie-Xin-Tang by HPLC”, Phytochem Analysis., 17(6), 439-446. (SCI)
I-Hsiao Chen, Fang-Rong Chang, Chin-Chung Wu, Shu-Li Chen, Pei-Wen Hsieh, Hsin-Fu Yen, Ying-Chi Du, and Yang-Chang Wu*, 2006, “Cytotoxic Triterpenoids from the Leaves of Microtropis fokienensisJ. Nat. Prod., 69, 1543-1546. (SCI)
Hamad Hassan Issa, Sue-Ming Chang, Yu-Liang Yang, Fang-Rong Chang, Yang-Chang Wu*, 2006,” New sesquiterpene lactones from the aerial parts of Pseudoelephantopus spicatus”, Chem. Pharm. Bull., 54 , 1599-1601.(SCI)
Shin-Pin Chen, Chih-Hua Chao, Ho-Cheng Huang, Yang-Chang Wu, Chung-Kuang Lu, Chang-Feng Dai, Jyh-Horng Sheu, 2006,” New beta-caryophyllene-derived terpenoids from the formosan soft coral Sinularia gibberosa” , Bull. Chem. Soci. Japan, 79,1547-1551. (SCI)
Ho-Cheng Huang, Atallah F. Ahmed, Jui-Hsin Su, Chih-Hua Chao, Yang-Chang Wu, Michael Y. Chiang, Sheu, Jyh-Horng, 2006,” Crassocolides A-F, cembranoids with a trans-fused lactone from the soft coral Sarcophyton crassocaule”, J. Nat. Prod., 69, 1554-1559. (SCI)
Pei-Wen Hsieh, Tsong-Long Hwang, Chin-Chung Wu, Shin-Zan Chiang, Chung-I Wu, and Yang-Chang Wu*, 2007, “The Evaluation and Structure Activities Relationships of 2-Benzoylamino-Benzoic Esters and Their Analogues as Anti-inflammatory and Anti-platelet Aggregation Agents” Bio. Med. Chem. Lett., 17, 1812-1817. (SCI)
An-Shen Lin, Fang-Rong Chang, Hsin-Fu Yen, HannaMaria Björkeborn, Yang-Chang Wu*, 2007, “Novel Flavonoids of Thelypteris torresiana”, Chem. Pharm. Bull., 55, 635-637. (SCI)
Jui-Hsin Su, Chang-Feng Dai, Hsin-Hui Huang, Yang-Chang Wu, Ping-Jyun Sung, Chi-Hsin Hsu, and Jyh-Horng Sheu*, 2007, “Terpenoid-Related Metabolites from a Formosan Soft Coral Nephthea chabrolii”, Chem. Pharm. Bull., 55, 594-597. (SCI)
Jui-Hsin Su, Fang-Yee Lin, Ho-Cheng Huang, Chang-Feng Dai, Yang-Chang Wu, Wan-Ping Hu, Chi-Hsin Hsu, and Jyh-Horng Sheu*, 2007, “ Novel Steroids from the Soft Coral Nephthea chabrolii”, Tetrahedron, 63, 703-707. (SCI)
Ping-Jyun Sung*, Mei-Ru Lin, Jih-Jung Chen, Shen-Fan Lin, Yang-Chang Wu, Tsong-Long Hwang, and Lee-Shing Fang, 2007, “Hydroperoxysterols from the Tunicate Eudistoma sp.”, Chem. Pharm. Bull., 55, 666-668. (SCI)
Pei-Wen Hsieh, Zih-You Huang, Jyun-Hong Chen, Fang-Rong Chang,* Ching-Chung Wu, Yu-Liang Yang, Michael Y. Chiang, Ming-Hon Yen, Shu-Li Chen, Hsin-Fu Yen, Tilo Lübken, Wen-Chun Hung, and Yang-Chang Wu*, 2007, “Cytotoxic Withanolides from Tubocapsicum anomalumJ. Nat. Prod., 70, 747-753. (SCI)
Hui-Chiu Chang, Fang-Rong Chang, Yu-Chiu Wu, Mei-Ren Pan, Wen-Chun Hung, and Yang-Chang Wu*, 2007, “A Bioactive Withanolide Tubocapsanolide A inhibits proliferation of human lung cancer cells via repressing Skp2 expression.” Mol. Cancer Ther., 6, 1572-1578. (SCI)
Mohamed H. Abd El-Razek, Yang-Chang Wu*, and Fang-Rong Chang*, 2007, “Sesquiterpene Coumarins from Ferula foetida ”, J. Chin. Chem. Soc., 54, 235-238. (SCI)
Yung-Husan Chen, Fang-Rong Chang, Yih-Jer Lin, Lisu Wang, Jinn-Fen Chen, Yang-Chang Wu*, Ming-Jiuan Wu*, 2007, “Identification of Phenolic Antioxidants from Sword Brake Fern (Pteris ensiformis Burn.)” Food Chem., 105, 48-56. (SCI)
An-Shen Lin, Kyoko Nakagawa-Goto, Fang-Rong Chang, Donglei Yu, Susan L. Morris-Natschke, Chin-Chung Wu, Shu-Li Chen, Yang-Chang Wu*, Kuo-Hsiung Lee*, 2007, “First Total Synthesis of Protoapigenone and its Analogs as Potent Cytotoxic Agents” J. Med. Chem., 50, 3921-3927 (SCI)
Wei-Ya Wang, Pei-Wen Hsieh, Yang-Chang Wu*, Chin-Chung Wu, 2007, “ Synthesis and pharmacological evaluation of novel β-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. , Biochemical Pharmacology. 74, 601-611 (SCI)
Ahmed AF, Shu-Hui Tai, Yang-Chang Wu, Jyh-Horng Sheu, 2007, “ Sinugrandisterols A-D, trihydroxysteroids from the soft coral Sinularia gyandilobata.”, Steroids, 72 , 368-374 (SCI)
Chin-Chung Wu, Chung-I Wu, Wei-Ya Wang, Yang-Chang Wu*,2007, “ Low concentrations of resveratrol potentiate the antiplatelet effect of prostaglandins.”, Planta Medica, 73, 439-443. (SCI)
Hui-Chi Hung, Wei-Jern Tsai, Chia-Ching Liaw, Shih-Hsiung Wu, Yang-Chang Wu,* Yao-Haur Kuo,* 2007, “Antiplatelet Aggregation Triterpene Soponins from the Galls of Saphindus mukorssi.”, Chem. Pharm. Bull., 55, 1412-1415. (SCI)
Yu-Hsuan Lan, Hsin-Yu Wang, Chin-Chung Wu, Shu-Li Chen, Chao-Lin Chang, Fang-Rong Chang*, and Yang-Chang Wu*, 2007, “New Constituents from Stems of Artabotrys uncinatus.”, Chem. Pharm. Bull., 55, 1597-1599. (SCI)
Chih-Hua Chao, Ho-Cheng Huang, Yang-Chang Wu, Chung-Kuang Lu, Chang-Feng Dai, and Jyh-Horng Sheu*, 2007, “Glycolipids from the Formosan Soft Coral Lobophytum crassum.”, Chem. Pharm. Bull., 55, 1720-1723. (SCI)
Jen-Hao Hsu, Yang-Chang Wu, I-Min Liu, and Juei-Tang Cheng,* 2007, “Dioscorea as the Principal Herb of Die-Huang-Wan, a Widely Used Herbal Mixture in China, for Improvement of Insulin Resistance in Fructose-rich Chow-fed Rats.”, J. Ethnopharmacol., 112, 577-584. (SCI)
Ping-Jyun Sung, Michael Y. Chiang, Wei-Tse Tsai, Jui-Hsin Su, Yu-Mine Su and Yang-Chang Wu, 2007, “ Chlorinated briarane-type diterpenoids from the gorgonian coral Ellisella robusta (Ellisellidae).”, Tetrahedron, 63, 12860-12865. (SCI)
Shin-Pin Chen, Jui-Hsin Su, Atallah Fouad Ahmed, Chang-Fang Dai, Yang-Chang Wu and Jyh-Horng Sheu, 2007, “Xeniaphyllane-Derived Terpenoids from the Formosan Soft Coral Sinularia gibberosa.”, Chem. Pharm. Bull., 55,1471-1475. (SCI)
Yu-Liang Yang, Sue-Ming Chang, Chin-Chung Wu, Pei-Wen Hsieh, Shu-Li Chen, Fang-Rong Chang*, Wen-Chen Hung, Hamad H. Issa, and Yang-Chang Wu*, 2007, “Cytotoxic Sesquiterpene Lactones from Pseudoelephantopus spicatus.”, J. Nat. Prod., 70, 1761-1765. (SCI)
Yu-Liang Yang, Chun-Ping Lu, Mao-Yen Chen, Kuei-Yu Chen, Yang-Chang Wu, and Shih-Hsiung Wu,* 2007, “Cytotoxic Polyketides Containing Tetramic Acid Moieties Isolated from the Fungus Myceliophthora Thermophila: Elucidation of the Relationship between Cytotoxicity and Steroconfiguration.”, Chem. Eur. J., 13, 6985-6991. (SCI)
Chia-Lin Lee, Fang-Rong Chang, Pei-Wen Hsieh, Michael-Y Chiang, Chin-Chung Wu, Zih-You Huang, Yu-Hsuan Lan, Mei Chen, Kuo-Hsiung Lee, Hsin-Fu Yen, Wen-Chun Hung, Yang-Chang Wu*, 2008, “ Cytotoxic ent-abietane diterpenes from Gelonium aequoreum ”, Phytochemistry, 69, 276-287. (SCI)
Yung-Husan Chen, Fang-Rong Chang, Yih-Jer Lin, Lisu Wang, Jinn-Fen Chen, Yang-Chang Wu*, Ming-Jiuan Wu*, 2008, “Identification of Antioxidants from Rhizome of Davallia solida”, Food Chem. 107, 684-691. (SCI)
Yu-Liang Yang, Kuo-Feng Hua, Pei-Hsuan Chuang, Shih-Hsiung Wu, Kuen-Yuh Wu, Fang-Rong Chang, Yang-Chang Wu*, 2008, “New cyclic peptides from the seeds of Annona squamosa L. and their anti-inflammatory activities ”, J. Agric. Food Chem., 56, 386-392. (SCI)
Yi-Chen Chia, Fang-Rong Chang, Chin-Chuang Wu, Michael Y.-N. Chiang, Yu-Hsuan Lan, Keh-Shaw Chen,* and Yang-Chang Wu*, 2008, ” Two Anti-platelet Aggregation Coumarins from the Leaves of Murraya omphalocarpa”, Molecules, 13, 122-128. (SCI)
Yung-Husan Chen, Fang-Rong Chang, Mei-Chin Lu, Pei-Wen Hsieh, Ming-Jiuan Wu, Ying-Chi Du and Yang-Chang Wu*, 2008, “New Benzoyl Glucosides and Cytotoxic Pterosin Sesquiterpenes from Pteris ensiformis Burm”, Molecules, 13, 255-266. (SCI)
Pei-Wen Hsieh*, Shin-Zan Chiang, Chin-Chung Wu, Yi-Ching Lo, Yu-Tzu Shih, Yang-Chang Wu*, 2008, “Synthesis and Anti-platelet Evaluation of 2-Benzoylaminobenzoate Analogs”, Bioorg. Med. Chem., 16, 5803-5814. (SCI)
Atallah F. Ahmed, Zhi-Hong Wen, Jui-Hsin Su, Ya-Ting Hsieh, Yang-Chang Wu, Wan-Ping Hu and Jyh-Horng Sheu, 2008,”Oxygenated Cembranoids from a Formosan Soft Coral Sinularia gibberosa.”, J. Nat. Prod., 71, 179-185 (SCI)
Chih-Chuang Liaw, Yu-Liang Yang, Mei Chen, Fang-Rong Chang,* Shu-Li Chen, and Yang-Chang Wu, * 2008, “Mono-Tetrahydrofuran Annonaceous Acetogenins from Annona squamosa as Cytotoxic Agents and Calcium Ion Chelators”, J. Nat. Prod., 71, 764-771. (SCI)
Wen-Ying Chen, Fang-Rong Chang, Zih-You Huang, Jyun-Hong Chen, Yang-Chang Wu*, Chin-Chung Wu*, 2008, “Tubocapsenolide A, A Novel Withanolide, Inhibits Proliferation and Induces Apoptosis in MDA-MB-231 cells by Thiol Oxidation of Heat Shock Proteins”, J. Biol. Chem., 25, 17184-17193. (SCI)
Atallah F. Ahmed, Shu-Hui Tai, Zhi-Hong Wen, Jui-Hsin Su, Yang-Chang Wu, Wan-Ping Hu, and Jyh-Horng Sheu, 2008, “A C-3 Methylated Isocembranoid and 10-Oxocembranoids from a Formosan Soft Coral, Sinularia grandilobata”, J. Nat. Prod., 71 (6), 946–951.(SCI)
Hsueh-Ling Chang, Jinu-Huang Su, Yao-Tsung Yeh, Yi-Chen Lee, Huey-May Chen, Yang-Chang Wu * and Shyng-Shiou F. Yuan*, 2008, Protoapigenone, a novel flavonoid, inhibits ovarian cancer cell growth in vitro and in vivo, Cancer Lett., 267: 85-95.(SCI)
Han-Lin Chang, Fang-Rong Chang, Jin-Shan Chen, Hui-Po Wang, Yi-Hsiu Wu, Chien-Chiao Wang, Yang-Chang Wu* and Tsong-Long Hwang*, 2008, “Inhibitory effects of 16-hydroxycleroda-3,13(14)E-dien-15-oic acid on superoxide anion and elastase release in human neutrophils through multiple mechanisms”, Eur J Pharmacol., 586:332-339.(SCI)
Hsueh-Ling Chang, Yang-Chang Wu*, Jinu-Huang Su, Yao-Tsung Yeh, and Shyng-Shiou F, 2008, “Protoapigenone, a novel flavonoid, induces apoptosis in human prostate cancer cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase 1/2.”, J Pharmacol Exp Ther., 325:841-9. (SCI)
Hui-Chi Huang, Ming-Der Wu, Wei-Jern Tsai, Sin-Chung Liao, Chia-Ching Liaw, Li-Chuan Hsu, Yang-Chang Wu* and Yao-Haur Kuo, 2008, “Triterpenoid saponins from the fruits and galls of Sapindus mukorossi”, Phytochemistry, 69:1609-16. (SCI)
Shou-Fang Wu, Pei-Wen Hsieh, Chin-Chung Wu, Chia-Lin Lee, Shu-Li Chen, Chi-Yu Lu, Tian-Shung Wu, Fang-Rong Chang*, Yang-Chang Wu*, 2008, “Camptothecinoids from the seeds of Taiwanese Nothapodytes foetidaMolecules, 13, 1361-1371. (SCI)
Chia-Lin Lee, Kyoko Nakagawa-Goto, Donglei Yu, Yi-Nan Liu, Kenneth F. Bastow, Susan L. Morris-Natschke, Fang-Rong Chang, Yang-Chang Wu* and Kuo-Hsiung Lee*, 2008, “Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis”, Bioorg Med Chem Lett.,18,4275-7277. (SCI)
Yu-Li Chen, Yu-Hsuan Lan, Pei-Wen Hsieh, Chin-Chung Wu, Shu-Li Chen, Chiao-Ting Yen, Fang-Rong Chang,* Wen-Chun Hung, and Yang-Chang Wu*, 2008, “Bioactive Cembrane Diterpenoids of Anisomeles indicaJ. Nat. Prod., 71, 1207-1212. (SCI)
Ming-Jung Wu,* Chiao-Pei Chen, Yang-Chang Wu, and Cheng-Lin Lee, 2008, “ Synthesis of (4R,15R,16R,21S)-Rollicosin and Its 4S Epimer.”, Eur. J. Org. Chem., 854-861. (SCI)
Hsiao Chen, Ying-Chi Du, Mei-Chin Lu, Pei-Wen Hsieh, Chin-Chung Wu, Shu-Li Chen, Hsin-Fu Yen, Fang-Rong Chang*, and Yang-Chang Wu*, 2008, “New Lupane-type Triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and Apoptotic Effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al”, J. Nat. Prod., 71, 1352-1357. (SCI)
Chia-Lin Lee, Po-Ching Huang, Pei-Wen Hsieh, Tsong-Long Hwang, Chih-Chuang Liaw, Fang-Rong Chang*, and Yang-Chang Wu*, 2008, “Chemical Constituents from Xanthium strumarium and (8S)-(-)-Xanthienopyran, a New Inhibitor of fMLP/CB induced Superoxide Anion Generation by Neutrophils” Planta Med., 1276-1279. (SCI)
Pei-Hsuan Chuang, Pei-Wen Hsieh, Yu-Liang Yang, Kuo-Feng Hua, Fang-Rong Chang, Jentaie Shiea, Shih-Hsiung Wu, Yang-Chang Wu*, 2008, “cyclopeptides with anti-inflammatory activities from the seeds of Annona montana.” J. Nat. Prod., 71, 1365-1370. (SCI)
Ko Yu Liu, Yang-Chang Wu, I-Min Liu, Wen Chen Yu, and Juei-Tang Cheng, 2008, Release of acetylcholine by syringin, an active principle of Eleutherococcus senticosus, to raise insulin secretion in Wistar rat Neurosci Lett., 434, 195-199. (SCI)
Chih-Hua Chao, Zhi-Hong Wen, Yang-Chang Wu, Hsiao-Chien Yeh, and Jyh-Horng Sheu* 2008, Cytotoxic and Anti-inflammatory Cembranoids from the Soft Coral Lobophytum crassum. J. Nat. Prod., 71, 1819–1824. (SCI)
Hsia-Fen Hsu, Jer-Yiing Houng, Chih-Feng Kuo, Nina Tsaod, and Yang-Chang Wu*, 2008, Glossogin, a novel phenylpropanoid from Glossogyne tenuifolia, induced apoptosis in A549 lung cancer cells. Food Chem Toxicol. 46, 3785-3791. (SCI)
Chung-Jen Chen, Martin Michaelis, Hseng-Kuang Hsu, Chin-Chuan Tsai, Kunder D. Yang, Yang-Chang Wu, Jindrich Cinatl Jr, and Hans Wilhelm Doerr*, 2008, Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication. J Ethnopharmacol. 120, 108-111. (SCI)
Henry W.-C. Leung, M.-J. Hour, W.-T. Chang, Y.-C. Wu, M.-Y. Lai, M.-Y. Wang and H.-Z. Lee* 2008, “P38-associated pathway involvement in apoptosis induced by photodynamic therapy with Lonicera japonica in human lung squamous carcinoma CH27 cells”,  Food and Chemical Toxicology,46, 3389-3400. (SCI)
Mei-Chin Lu, Shiuh-Lin Hwang, Fang-Rong Chang, Yung-Husan Chen, Chih-Sheng Hung, Chun-Li Wang, Yao-Hsiung Chu, Shu-Jua Pan and Yang-Chang Wu*, 2009, “Immunostimulatory effect of Antrodia cinnamomea extract on functional maturation of dendritic cells.”, Food. Chemistry. 113, 1049–1057. (SCI)
Mei-Chin Lu, Ying-Chi Du, Jiunn-Jye Chuu, Shiuh-Lin Hwang, Pao-Chuan Hsieh, Fang-Rong Chang* and Yang-Chang Wu*, 2009, “Active extracts of wild fruiting bodies of Antrodia camphorate (EEAC)-induce leukemia HL60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A.” , Arch of Toxicol. 83, 121-129. (SCI)
Chia-Lin Lee, Fang-Rong Chang, Ming-Hon Yen, Donglei Yu, Yi-Nan Liu, Kenneth F. Bastow, Susan L. Morris-Natschke, Yang-Chang Wu* and Kuo-Hsiung Lee*, 2009, “Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis”, J. Nat. Prod. 72, 210-213. (SCI)
Chiao-Ting Yen, Pei-Wen Hsieh, Tsong-Long Hwang, Yu-Hsuan Lan, Fang-Rong Chang and Yang-Chang Wu*, 2009, “Flavonol glycosides from Muehlenbeckia platyclada and their anti-inflammatory activity” Chem. Pharm. Bull. 57, 280-282. (SCI)
Tsong-Long Hwang*, Guo-Long Li, Yu-Hsuan Lan, Yi-Chen Chia, Pei-Wen Hsieh, Yi-Hsiu Wu, Yang-Chang Wu, 2009, “Potent inhibition of superoxide anion production in activated human neutrophils by isopedicin, a bioactive component of the Chinese medicinal herb Fissistigma oldhamiiFree Radic. Biol. Med. 46, 520-528. (SCI)
Shin-Pin Chen, Jui-Hsin Su, Hsiao-Chien Yeh, Atallah Fouad Ahmed, Chang-Feng Dai, Yang-Chang Wu, and Jyh-Horng Sheu*, 2009, “Novel norhumulene and xeniaphyllane-derived terpenoids from a formosan soft coral Sinularia gibberosaChem. Pharm. Bull. 57, 162-166. (SCI)
Mei-Ren Pan, Hui-Chiu Chang, Yang-Chang Wu, Chao-Cheng Huang, and Wen-Chun Hung*, 2009, “Tubocapsanolide A inhibits transforming growth factor-beta-activating kinase 1 to suppress NF-kappaB-induced CCR7” J. Biol. Chem. 284, 2746-2754. (SCI)
Shang-Kwei Wang, Chang-Yih Duh, Yang-Chang Wu, Yu Wang, Ming-Chu Cheng, Keryae Soong and Lee-Shing Fang. 2009, Cytotoxic Cembranoids from the Soft Coral Lobophytum michaelae. J. Nat. Prod., 72, 324. (SCI)
Chiao-Ting Yen, Tsong-Long Hwang, Yang-Chang Wu*, and Pei-Wen Hsieh*. 2009, Design and synthesis of new N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides as anti-inflammatory agents. Eur. J. Med. Chem., 44, 933-1940. (SCI)
An-Shen Lin, Chia-Rong Lin, Ying-Chi Du, Tilo Lübken, Michael Y. Chiang, I-Hsiao Chen, Chin-Chung Wu, Tsong-Long Hwang, Shu-Li Chen, Ming-Hong Yen, Fang-Rong Chang, Yang-Chang Wu*, 2009, Acasiane A and B and Farnesirane A and B, Diterpene Derivatives from the Roots of Acacia farnesiana. Planta Med., 75,256-61 (SCI)
Yu-Yi Hou, Mu-Ling Wu, Yu-Chun Hwang, Fang-Rong Chang, Yang-Chang Wu*, and Chin-Chung Wu*, 2009, The natural diterpenoid ovatodiolide induces cell cycle arrest and apoptosis in human oral squamous cell carcinoma Ca9-22 cells. Life Sci., 85,26-32 (SCI)
I-Hsiao Chen, Mei-Chin Lu, Ying-Chi Du, Ming-Hong Yen, Chin-Chung Wu, Yung-Husan Chen, Chih-Sheng Hung, Shu-Li Chen, Fang-Rong Chang* and Yang-Chang Wu*, 2009, Cytotoxic Triterpenoids from the Stems of Microtropis japonica. J. Nat. Prod. 72,1231-1236. (SCI)
Huei-Mei Chen, Yang-Chang Wu, Yi-Chen Chia, Fang-Rong Chang, Hseng-Kuang Hsu, Ya-Ching Hsieh, Chih-Chen Chen, and Shyng-Shiou Yuan, 2009, Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROS-mediated anti-cancer activity in human prostate cancer cells. Cancer Lett. 286,161-71. (SCI)
Ying-Chi Du, An-Shen Lin, Chin-Chung Wu, Pei-Wen Hsieh, Yung-Husan Chen, I-Hsiao Chen, Shu-Li Chen, Hsin-Fu Yen, Tilo Lübken, Fang-Rong Chang, Yang-Chang Wu*, 2009, “New Cytotoxic Lupane Triterpenes from Perrottetia arisanensis.”, Planta Med., 75,848-855. (SCI)
Chien-Chih Chiu, Hsueh-Wei Chang, Da-Wei Chuang, Fang-Rong Chang, Yu-Ching Chang, Yu-Shan Cheng, Ming-Tz Tsai, Wan-Yu Chen, Su-Shuo Lee, Chih-Kuang Wang, Jeff Yi-Fu Chen, Hui-Min Wang, Chao-Chieh Chen, Yin-Chang Liu,* Yang-Chang Wu,* 2009, “Fern plant-derived protoapigenone leads to DNA damage, apoptosis and G2/M arrest in lung cancer cell line H1299”, DNA and Cell Biology, 28,501-506. (SCI)
Yu-Hsuan Lan, Fang-Rong Chang,* Mei-Jung Pan, Chin-Chung Wu, Sue-Jing Wu, Su-Li Chen, Shyh-Shyan Wang, Ming-Jung Wu, Yang-Chang Wu,* 2009, “New Cytotoxic Withanolides from Physalis peruviana”, Food Chemistry, 116, 462-469. (SCI)
Chia-Lin Lee, Lien-Chai Chiang, Li-Hung Cheng, Chih-Chuang Liaw, Mohamed H. Abd El-Razek, Fang-Rong Chang, * and Yang-Chang Wu*, 2009, “Anti-influenza A Viral (H1N1) and Cytotoxic Agents from Ferula assafoetida”, J. Nat. Prod., 72, 1568-1572.(SCI)
Shih-Chung Wang, Mei-Chin Lu, Hsiu-Lin Chen, Hsing-I Tseng, Yu-Yuan Ke, Yang-Chang Wu*, and Pei-Yu Yang. 2009, “Cytotoxicity of calotropin is through caspase activation and downregulation of anti-apoptotic proteins in K562 cells” Cell Biol Int.,33, 1230-1236. (SCI)
Ping-Jyun Sung,* Bo-Yuan Chen, Mei-Ru Lin, Tsong-Long Hwang, Wei-Hsien Wang, Jyh-Horng Sheu, and Yang-Chang Wu*. 2009, “Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum” Mar Drugs., 23, 7, 472-482. (SCI)
Hsia-Fen Hsu, Yang-Chang Wu, Lei-Chin Chen, Jer-Yiing Houng*, 2009, "Induction of apoptosis of A549 lung cancer cell line by dehydrocostus lactone isolated from Glossogyne tenuifolia.", Journal of Food and Drug Analysis, 17,107-115. (SCI)
Pei-Wen Hsieh, Li-Chi Hsu, Chern-Hsiung Lai, Chin-Chung Wu, Tsong-Long Hwang, Yin-Ku Lin, and Yang-Chang Wu. 2009, “Evaluation of the bioactivities of extracts of endophytes isolated from Taiwanese herbal plants” World J Microbiol Biotechnol, 25, 1461-1469. (SCI)
Bo-Wei Chen, Yang-Chang Wu, Michael Y. Chiang, Jui-Hsin Su, Wei-Hsien Wang, Tung-Yung Fan and Jyh-Horng She*. 2009, “Eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex” Tetrahedron 65, 7016-7022. (SCI)
Chao-Lin Chang, Guei-Jane Wang , Li-Jie Zhang, Wen-Jen Tsai, Ru-Yin Chen, Yang-Chang Wu*,Yao-Haur Kuo, 2010, “Cardiovascular protective flavonolignans and flavonoids from Calamus quiquesetinervius”,Phytochemistry,71,271-279. (SCI)
Chao-Lin Chang, Li-Jie Zhang, Ru-Yin Chen, Chin-Chung Wu, Hui-Chi Huang, Michael C. Roy, Jhih-Ping Huang, Yang-Chang Wu*, Yao-Haur Kuo*, 2010,” Quiquelignan A–H, eight new lignoids from the rattan palm Calamus quiquesetinervius and their antiradical, anti-inflammatory and antiplatelet aggregation activities”, Bioorganic & Medicinal Chemistry, 18, 518–525. (SCI)
Pei-Yu Yang, Ming-Feng Chen, Chi-Hong Tsai, Dan-Ning Hu, Fang-Rong Chang,  Yang-Chang Wu*, 2010, “Involvement of caspase and MAPK activities in norcantharidin-inducedcolorectal cancer cell apoptosis”, Toxicology in Vitro, 24, 766–775. (SCI)
Tai-Hung Chen, Yu-Hao Huang, Jhih-Jhang Lin, Bing-Chung Liau, Sheng-Yang Wang, Yang-Chang Wu, Ting-Ting Jong* 2010, “Cytotoxic Lignan Esters from Cinnamomum osmophloeum” Planta Med., 76, 613-619. (SCI)
Yu-Tzu Shih, Ya-Yun Hsu, Fang-Rong Chang, Yang-Chang Wu, Yi-Ching Lo,*“6-Hydroxycleroda-3,13-dien-15,16-olide Protects Neuronal Cells from Lipopolysaccharide-Induced Neurotoxicity through the Inhibition of Microglia-Mediated Inflammation” Planta Med.,76, 120-127. (SCI)
Fang-Rong Chang, Yi-Chung Hsieh, Yung-Fu Chang, Kuo-Hsiung Lee, Yang-Chang Wu, Li-Kwan Chang,* 2010, “Inhibition of the Epstein-Barr virus lytic cycle by moronic acid”, Antiviral Res, 85, 490-495. (SCI)
Chiao-Ting Yen, Chin-Chung Wu, Jin-Ching Lee, Shu-Li Chen, Susan L. Morris-Natschke, Pei-Wen Hsieh,* Yang-Chang Wu,* 2010, “Cytotoxic N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides: Structure-activity relationships and synergistic studies ” Eur. J. Med. Chem. 45, 2494-2502. (SCI)
Chia-Ting Yen, Kyoko Nakagawa-Goto, Tsong-Ling Hwang, Pei-Chi Wu, Susan L. Morris-Natschke, Wang-Chun Lai, Kenneth F. Bastow, Fang-Rong Chang, Yang-Chang Wu,* Kuo-Hsiung Lee,* 2010, “ Antitumor agents. 271: Total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents ” Bioorg. Med. Chem. Lett. 20, 1037-1039. (SCI)
Ching-Yu Yen, Chien-Chih Chiu, Fang-Rong Chang, Jeff Yi-Fu Chen, Chi-Ching Hwang, You-Cheng Hseu, Hsin-Ling Yang, Alan Yueh-Luen Lee, Ming-Tz Tsai, Zong-Lun Guo, Yu-Shan Cheng, Yi-Chang Liu, Yu-Hsuan Lan, Yu-Ching Chang, Ying-Chin Ko, Hsueh-Wei Chang,* Yang-Chang Wu* 2010, “4-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest.” BMC Cancer 10:46 (8 pages)
Guey-Horng Wang, Ho-Cheng Huang, Jui-Hsin Su, Yang-Chang Wu, Jyh-Horng Sheu,* 2010 “Paralemnolins J-P, new sesquiterpenoids from the soft coral Paralemnalia thyrsoide.” Chem. Pharm. Bull. 58, 30-33.
I-Ta Lee, Chih-Chung Lin, Yang-Chang Wu, Chuen-Mao Yang*, 2010, “TNF-α induces matrix metalloproteinase-9 expression in A549 cells: role of TNFR1/TRAF2/PKCα-dependent signaling pathways” J. Cell Physio. 224, 454-464.
Chih-Yang Liu, Tsong-Long Hwang, Mei-Ru Lin, Yung-Husan Chen, Yu-Chia Chang, Lee-Shing Fang, Wei-Hsien Wang, Yang-Chang Wu* and Ping-Jyun Sung* 2010 “Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (Clavulariidae)” Mar. Drugs, 8, 2014-2020. (SCI)
Tsong-Long Hwang*, Chien-Chiao Wang, Yao-Haur Kuo, Hui-Chi Huang, Yang-Chang Wu, Liang-Mou Kuo, Yi-Hsiu Wu, 2010, “The hederagenin saponin SMG-1 is a natural FMLP receptor inhibitor that suppresses human neutrophil activation” Biochem. Pharmacol., 80, 1190-1200. (SCI)
Chih-Chung Liaw, Tung-Ying Wu, Fang-Rong Chang and Yang-Chang Wu,* 2010, “Historic Perspectives on Annonaceous Acetogenins from the Chemical Bench to Preclinical Trials” Planta Med., 76(13), 1390-1404. (SCI)
Chao-Lin Chang, Li-Jie Zhang, Ru Yi Chen, Li-Ming Yang Kuo, Jhih-Ping Huang, Hui-Chi Huang, Kuo-Hsiung Lee, Yang-Chang Wu* and Yao-Haur Kuo* 2010, “ Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinerviusJ. Nat. Prod.,73(9), 1482-1488. (SCI)
Chih-Hua Chao, Kuei-Ju Chou, Guey-Horng Wang, Yang-Chang Wu, Li-Hsueh Wang, Jeng-Ping Chen, Jyh-Horng Sheu* and Ping-Jyun Sung* 2010, “Norterpenoids and related peroxides from the Formosan Marine sponge Negombata corticataJ. Nat. Prod., 73(9), 1538-1543. (SCI)
Yu-Tzu Shih, Po See Chen, Chi-Han Wu, Yu-Ting Tseng, Yang-Chang Wu*, Yi-Ching Lo*, 2010, “Arecoline, a major alkaloid of the areca nut, causes neurotoxicity through enhancement of oxidative stress and suppression of the antioxidant protective system.” Free Radic. Bio. Med.,49, 1471-1479. (SCI)
Chin-Chung Wu*, Shih-Yun Wu, Chieh-Yu Liao, Che-Ming Teng, Yang-Chang Wu, Sheng-Chu Kuo, 2010, “The roles and mechanism s of PAR4 and P2Y12/phosphatidylinositol 3-kinase pathway in maintaining thrombin-induced aggregation.” Br. J. Pharmacol., 161(3), 643-658. (SCI)
Chia-Lin Lee, Yung-Chih Liao, Tsong-Long Hwang, Chin-Chung Wu, Fang-Rong Chang,* Yang-Chang Wu* , 2010, “Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea.” Bioorg. Med. Chem. Lett., 20, 7354-7357. (SCI).
Bo-Wei Chen, Shu-Ming Chang, Chiung-Yao Huang, Chih-Hua Chao, Jui-Hsin Su, Zhi-Hong Wen, Chi-Hsin Hsu, Chang-Feng Dai, Yang-Chang Wu, and Jyh-Horng Sheu*, 2010, “Hirsutalins A-H, eunicellin-based diterpenoids from the soft coral Cladiella hirsute.” J. Nat. Prod.,73, 1785-1791. (SCI)
Yung-Husan Chen, Chia-Ying Tai, Tsong-Long Hwang, Ching-Feng Weng, Jan-Jung Li, Lee-Shing Fang, Wei-Hsien Wang, Yang-Chang Wu*, and Ping-Jyun Sung*, 2010, “Cladielloides A and B: new eunicellin-type diterpenoids from an Indonesian octocoral Cladiella sp.” Mar. Drugs, 8, 2936-2945. (SCI)
Chia-Lin Lee, Chi-Huan Huang, Hui-Chun Wang, Da-Wei Chuang, Ming-Jung Wu, Sheng-Yang Wang, Tsong-Long Hwang, Chin-Chung Wu, Yeh-Long Chen, Fang-Rong Chang,* Yang-Chang Wu*, 2011, “First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents.” Org. Biomol. Chem., 9 (1), 70-73. (SCI)
Yu-Hsuan Lan, Yang-Chang Wu, Kai-Wei Wu, Jing-Chung Chung, Chi-Cheng Lu, Yuan-Liang Chen, Tian-Shung Wu*, Jai-Sing Yang*, 2011, “Death receptor 5-mediated TNFR family signaling pathways modulate γ-humulene-induced apoptosis inhuman colorectal cancer HT29 cells” Oncol. Rep., 25, 419-424. (SCI)
Jin-Ching Lee*, Wei-Chun Chen, Shou-Fang Wu, Chin-kai Tseng, Ching-Yi Chiou, Fang-Rong Chang, Shih-hsien Hsu, Yang-Chang Wu*, 2011, “Anti-hepatitis C virus activity of Acacia confuse extract via suppressing cyclooxygenase-2” Antiviral Res., 89, 35-42. (SCI)
Bang-Jau You, Yang-Chang Wu, Bo-Ying Bao, Chi-Yu Wu, Ya-Win Yang, Yu-Hao Chang, Hong-Zin Lee*, 2011, “Rottlerin inhibits Lonicera japonica-induced photokilling in human lung cancer cells through cytoskeleton-related signaling cascade.” Evid. Based Complement Alternat. Med. 193842, 9 pages. (SCI)
Yu-Ming Chung, Fang-Rong Chang, Tseng-Fu Tseng, Tsong-Long Hwang, Lei-Chin Chen, Shou-Fang Wu, Chia-Lin Lee, Zu-Yau Lin, Li-Yeh Chuang, Jinu-Huang Su*, Yang-Chang Wu*, 2011, “A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis.” Bioorg. Med. Chem. Lett. 21 (6), 1792-1794.(SCI)
Chien-Chih Lee, Yi-Hsiung Lin, Wen-Hsin Chang, Pei-Chin Lin, Yang-Chang Wu,* Jan-Gowth Chang, 2011, “Squamocin modulates histone H3 phosphorylation levels and induces G1 phase arrest and apoptosis in cancer cells” BMC Cancer, 11:58, 9 pages. (SCI)
Pei-Yu Yang, Ming-Feng Chen, Ying-Hsien Kao, Dan-Ning Hu, Fang-Rong Chang, and Yang-Chang Wu*, 2011, “Norcantharidin induces apoptosis of breast cancer cells: involvement of activities of mitogen activated protein kinases and signal transducers and activators of transcription” Toxicol. In Vitro. 25, 699-707. (SCI)
Bo-Wei Chen, Chih-Hua Chao, Jui-Hsin Su, Chung-Wei Tsai, Wei-Hsien Wang, Zhi-Hong Wen, Chiung-Yao Huang, Ping-Jyun Sung, Yang-Chang Wu and Jyh-Horng Sheu,* 2011, “Klysimplexins I-T, eunicellin-based diterpenoids from cultured soft coral Klyxum simplex..” Org. Biomol. Chem., 9, 834-844. (SCI)
Mei-Hui Lin, Fang-Rong Chang, Mu-Yi Hua, Yang-Chang Wu,* Shih-Tung Liu*, 2011, “Inhibitory effects of 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose on biofilm formation by Staphylococcus aureus.” Antimicrob Agents Chemother. 55(3), 1021-2027(SCI)
Huei-Mei Chen, Fang-Rong Chang, Ya-Ching Hsieh, Yu-Jen Cheng, Kun-Chou Hsieh, Lih-Min Tsai, An-Shen Lin, Yang-Chang Wu,* Shyng-Shiou Yuan*, 2011, “A novel synthetic protoapigenone analogue, WYC02-9, induces DNA damage and apoptosis in DU145 prostate cancer cells through generation of reactive oxygen species.” Free Radic. Bio. Med. 50, 1151-1162. (SCI)
Bo-Wei Chen, Shu-Ming Chang, Chiung-Yao Huang, Jui-Hsin Su, Zhi-Hong Wen, Yang-Chang Wu and Jyh-Horng Sheu,* 2011, “Hirsutosterols A-G, polyoxygenated steroids from a Formosan soft coral Cladiella hirsuta.” Org. Biomol. Chem., 9, 3272-3278. (SCI)
Chien-Chih Chiu, Po-Len Liu, Kuang-Jing Huang, Hui-Min Wang, Kuo-Feng Chang, Chon-Kit Chou, Fang-Rong Chang, Inn-Wen Chong, Kang Fang, Jia-Shing Chen, Hsueh-Wei Chang,* Yang-Chang Wu,* 2011, “Goniothalamin inhibits growth of human lung cancer cells through DNA damage, apoptosis and reduced migration ability.” J. Agr. Food Chem. 59 (8), 4288-4293. (SCI)
Shou-Fang Wu, Fang-Rong Chang,* Sheng-Yang Wang, Tsong-Long Hwang, Chia-Lin Lee, Shu-Li Chen, Chin-Chung Wu, and Yang-Chang Wu*, 2011, “Anti-inflammatory and cytotoxic neoflavonoids and benzofurans from Pterocarpus santalinus.” J. Nat. Prod. 74 (5), 989-996. (SCI)
Yi-Hsiung Lin, Chien-Chih Lee, Wen-Li Chan, Wen-Hsin Chang, Yang-Chang Wu*, Jan-Gowth Chang*, 2011, “16-Hydroxyxleroda-3,13-dien-15,16-olide deregulates PI3K and Aurora B activities that involve in cancer cell apoptosis.” Toxicology 285 (1-2), 72-80. (SCI)
Chih-Hua Chao, Kuei-Ju Chou, Zhi-Hong Wen, Guey-Hormg Wang, Yang-Chang Wu, Chang-Fang Dai and Jyh-Horng Sheu,* 2011, “Paraminabeolides A-F, cytotoxic and anti-inflammatory marine withanolides from the soft coral Paraminabea acronocephala.” J. Nat. Prod. 74 (5), 1132-1141.(SCI)
James Cheng-Chung Wei, Jeng-Hsien Yen, Suh-Hang Hank Jup, Wei-Chiao Chen, Yu-Shiuan Wang, Yi-Ching Chiu, Tusty-Jiuan Hsieh, Yuh-Cherng Guo, Chun-Huang Huang, Ruey-Hong Wong, Hui-Po Wang, Ke-Li Tsai, Yang-Chang Wu, Hsueh-Wei Chang, Edward His, Wei-Pin Chang, Wei-Chiao Chang*, 2011, “Association of ORAl1 haplotypes with the risk of HLA-B27 positive ankylosing spondylitis.” PLoS One, 6 (6): e20426, page 1-6. (SCI)
Chia-Ying Tai, Yung-Husan Chen, Tsong-Long Hwang, Lee-Shing Fang, Wei-Hsien Wang, Ming-Chin Liu, Jui-Hsin Su, Yang-Chang Wu, and Ping-Jyun Sung*, 2011, “ Cladielloides C and D: novel eunicellin-based diterpenoids from an Indonesian Octocoral Cladielle sp.” Bull. Chem. Soc. Jpn. 84 (5), 531-536. (SCI)
Yung-Husan Chen, Chia-Ying Tai, Yin-Di Su, Yu-Chia Chang, Mei-Chin Lu, Ching-Feng Weng, Jui-Hsin Su, Tsong-Long Hwang, Yang-Chang Wu*, Ping-Jyun Sung*, 2011, “Discovery of new eunicellins from an Indonesian Octocoral Cladiella sp.” Mar. Drugs, 9, 934-943. (SCI)
Ping-Jyun Sung*, Jui-Hsien Wang, Jyh-Horng Sheu, Lee-Shing Fang, Yang-Chang Wu, Yung-Husan Chen, Hsu-Ming Chung, Yin-Di Su, Yu-Chia Chang, 2011, “Survey of briarane-type diterpenoids-part IV.” Heterocycles, 83 (6), 1241-1258. (SCI)
Juan-Cheng Yang, Mei-Chin Lu, Chia-Lin Lee, Guan-Yu Chen, Yan-Yu Lin, Fang-Rong Chang*, and Yang-Chang Wu*, 2011, “Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K.” Free Radic. Bio. Med. 51, 641-657. (SCI)
Chih-Chuang Liaw*, Wen-Ying Liao, Chien-Sheng Chen, Shu-Chuan Jao, Yang-Chang Wu, Chia-Ning Shen*, Shih-Hsiung Wu*, 2011, “The calcium-chelating capability of tetrahydrofuranic moieties modulates the cytotoxicity of annonaceous acetogenins.” Angew. Chem. Int. Ed. 50, 1-8. (SCI)
Bang-Jau You, Yang-Chang Wu, Ching-Yi Wu, Bo-Ying Bao, Mei-Yen Chen, Yen-Hwa Chang, Hong-Zin Lee*, 2011, “Proteomics displays cytoskeletal proteins and chaperones involvement in Hedyotis corymbosa-induced photokilling in skin cancer cells.” Exp Dermatol. 20 (8), 653-658. (SCI)
Shou-Fang Wu, Tsong-Long Hwang, Shu-Li Chen, Chin-Chung Wu, Emika Ohkoshi, Kuo-Hsiung Lee, Fang-Rong Chang*, Yang-Chang Wu*, 2011, “Bioactive components from the heartwood of Pterocarpus santalinus.” Bioorg. Med. Chem. Lett. 21, 5630-5632. (SCI)
Attila Hunyadi, Da-Wei Chuang, Balazs Danko, Michael Y. Chiang, Chia-Lin Lee, Hui-Chun Wang, Chin-Chung Wu, Fang-Rong Chang*, Yang-Chang Wu*, 2011, “Direct semi-synthesis of the anticancer lead-drug protoapigenone from apigenin, and synthesiss further new cytotoxic protoflavone derivatives.” PLoS One, 6 (8): e23922, page 1-10. (SCI)
Yu-Ming Chung, Hui-Chun Wang, Mohamed El-Shazly, Yann-Lii Leu, Ming-Ching Cheng, Chia-Lin Lee, Fang-Rong Chang*, Yang-Chang Wu*, 2011, “Antioxidant and tyrosinase inhibitory constituents from the desugared sugarcane extract, a by-product of sugar production.” J. Agric. Food Chem. 59(17), 9219-9225. (SCI)
Wan-Chun Lai, Hui-Chun Wang, Guan-Yu Chen, Juan-Cheng Yang, Michal Korinek, Chia-Jung Hsieh, Hiroshi Nozaki, Ken-Ichiro Hayashi, Chih-Chung Wu, Yang-Chang Wu, Fang-Rong Chang*, 2011, “Using the pER8: GUS reporter system to screen for phytoestrogens from Caesalpinia sappan.” J. Nat. Prod. 74 (8), 1698-1706. (SCI)
Yu-Tzu Shih, Ing-Jun Chen, Yang-Chang Wu, and Yi-Ching Lo*, 2011, “San-Huang-Xie-Xin-Tang Protects Against Activated Microglia- and 6-OHDA-induced Toxicity in Neuronal SH-SY5Y Cells.” Evid. Based Complement Alternat. Med., In press. (SCI)
Wen-Ying Chen, Yu-An Hsieh, Ching-I Tsai, Ya-Fei Kang, Fang-Rong Chang, Yang-Chang Wu*, Chin-Chung Wu* 2011, “Protoapigenone, a natural derivative of apigeninm, induces mitogen-activated protein kinase-dependent apoptosis in human breast cancer cells associated with induction of oxidative stress and inhibition of glutathione S-transferaseπ” Invest New Drugs. In press. (SCI)
Chao-Ping Tung, Fang-Rong Chang, Yang-Chang Wu, Da-Wei Chuang, Attila Hunyadi and Shih-Tung Liu*, 2011, “Inhibition of the Epstein-Barr virus lytic cycle by protoapigenone.” J. Gen. Virol. In press (SCI)
Yang-Chang Wu, Mann J. Hour, Wing C. Leung, Chi Y. Wu, Wen Z. Liu, Yu H. Chang, Hong Z. Lee*, 2011, “2-(Naphthalene-1-yl)-6-pyrrolidinyl-4-quinzaolinone inhibits skin cancer M21 cell proliferation through aberrant expression of microtubule and cell cycle.” The Journal of Pharmacology and Experimental Therapeutics in press (SCI)
Kung-Kai Kuo, Yi-Ling Chen, Lih-Ren Chen, Chien-Feng Li, Yu-Hsuan Lan, Fang-Rong Chang, Yang-Chang Wu, Yow-Ling Shiue*, 2011, “Involvement of phorbol-12-myristate-13-acetate-induced protein 1 in goniothalamin-induced TP53-dependent and –independent apoptosis in hepatocellular carcinoma-derived cells.” Toxicl. Appl. Pharmacol. in press (SCI)
Yu-Min Ko, Tung-Ying Wu, Yang-Chang Wu, Fang-Rong Chang, Jinn-Yuh Guh, Lea-Yea Chuang*, 2011, “Annonacin induces cell cycle-dependent growth arrest and apoptosis in estrogen receptor-α-related pathways in MCF-7 cells.” J. Ethnopharmacol. in press (SCI)

* Corresponding author

著作專書

Books
2002 吳永昌、吳天賞、林漢欽、徐鳳麟、陳建志、張永勳合著,衛生署中醫藥委員會出版:中藥對照用指標成分物理化學資料彙編,2002。
2003 吳永昌等編譯,教育部公告,國立編譯館主編:化學名詞,2003。
2004 吳永昌等合編,行政院衛生署編印:中華中藥典,2004。
2006 吳永昌, STUDIES IN NATURAL PRODUCTS CHEMISTRY VOLUME 33 BIOACTIVE NATURAL PRODUCTS (PART M) New Research and Development on the Formosan Annonaceous Plants,荷蘭,阿姆斯特丹, ELSEVIER, 2006。

 

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