空氣污染也可能影響大腦健康！中國醫大研究團隊揭開PM2.5與阿茲海默症的潛在關聯
日期：2026-10-27
資料來源：研究亮點｜Hsuan-Yu Huang、黃偉謙、賴志河等研究團隊
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空氣污染也可能影響大腦健康！中國醫大研究團隊揭開PM2.5與阿茲海默症的潛在關聯
我們每天呼吸的空氣，除了影響肺部與心血管健康，是否也可能悄悄增加大腦退化的風險？
中國醫藥大學黃偉謙教授參與領導的跨校研究團隊，在國際期刊《Redox Biology》發表重要研究成果，提出「PM2.5－胰島素阻抗－阿茲海默症」的整合性科學架構，揭示空氣污染可能影響大腦健康的重要途徑。
研究團隊綜合流行病學、動物與細胞研究證據，指出長期暴露於PM2.5可能引發慢性發炎與氧化壓力，並干擾人體胰島素訊號，使細胞無法有效利用與調節能量。
更值得注意的是，胰島素阻抗不僅與糖尿病有關，也可能影響大腦神經細胞功能、破壞血腦屏障，並干擾與阿茲海默症相關的異常蛋白質清除。
這項研究將環境污染、代謝失衡與神經退化疾病連結起來，為未來透過改善空氣品質、維持代謝健康及發展精準預防策略，降低失智症風險提供新的科學方向。
Can Air Pollution Affect Brain Health? CMU Researchers Reveal a Potential Link Between PM2.5 and Alzheimer's Disease
Could the air we breathe every day affect not only our lungs and cardiovascular system but also increase the risk of neurodegenerative diseases such as Alzheimer's disease?
A collaborative research team co-led by Professor Wei-Chien Huang of China Medical University (CMU) has published an important review in the international journal Redox Biology, introducing an integrated scientific framework known as the PM2.5–Insulin Resistance–Alzheimer's Disease Axis.
By synthesizing evidence from epidemiological, animal, and cellular studies, the researchers highlighted how long-term exposure to fine particulate matter (PM2.5) may trigger chronic inflammation, oxidative stress, and disruptions in insulin signaling, potentially affecting the body's ability to regulate cellular metabolism.
Importantly, insulin resistance is not only associated with diabetes but may also impair brain function, compromise the blood-brain barrier, and interfere with the clearance of abnormal proteins linked to Alzheimer's disease.
This research provides a new perspective on the interconnected relationships among environmental pollution, metabolic dysfunction, and neurodegeneration. It also highlights promising directions for future prevention strategies, including improving air quality, maintaining metabolic health, and developing targeted approaches to reduce Alzheimer's disease risk.
原文網址: https://www.sciencedirect.com/science/article/pii/S2213231726000297?via%3Dihub
研究團隊｜Research Team
中文:
第一作者：Hsuan-Yu Huang
共同通訊作者：黃偉謙、賴志河
中國醫藥大學與長庚大學跨校研究團隊
英文：
First Author: Hsuan-Yu Huang
Corresponding Authors: Wei-Chien Huang and Chih-Ho Lai
Collaborative Research Team, China Medical University and Chang Gung University
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