中醫藥結合3D列印再生醫學！中國醫大團隊開發促進骨骼修復的新型生醫材料
日期：2026-10-30
資料來源：研究亮點｜何佳哲、徐端隄、林彥宏、林宗立、周德陽、謝明佑等研究團隊
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中醫藥結合3D列印再生醫學！中國醫大團隊開發促進骨骼修復的新型生醫材料
當骨骼因嚴重外傷、疾病或手術造成大範圍缺損時，人體往往難以自行修復。如何幫助骨骼重新生長，一直是再生醫學的重要挑戰。
中國醫藥大學謝明佑、林宗立與周德陽研究團隊，在國際期刊《Journal of Nanobiotechnology》發表研究成果，結合傳統中藥「白鮮皮」、矽酸鈣生醫材料與3D列印技術，開發具有促進骨組織再生潛力的新型支架。
研究發現，這種支架不僅能提供骨骼生長的支撐結構，還能調節局部發炎反應，促使免疫細胞轉變為有利組織修復的狀態。
更重要的是，經調節的免疫細胞會釋放富含miR-21的細胞外囊泡，如同傳遞修復指令的微型信使，進一步促進幹細胞分化、血管新生與骨組織形成。
在兔子骨缺損實驗中，這項材料展現加速新生骨形成與成熟的效果。
這項研究展現中醫藥與現代生醫科技結合的創新潛力，也為未來骨缺損重建及精準再生醫療開啟新的發展方向。
Integrating Traditional Chinese Medicine with 3D Printing: CMU Researchers Develop Innovative Biomaterials for Bone Regeneration
When bones suffer extensive damage from severe injuries, diseases, or surgery, the body's natural healing ability may be insufficient to restore the missing tissue. Developing effective strategies to regenerate large bone defects remains a major challenge in regenerative medicine.
A collaborative research team led by Ming-You Shie, Tsung-Li Lin, and Der-Yang Cho of China Medical University (CMU) has published significant findings in the international journal Journal of Nanobiotechnology, introducing an innovative 3D-printed bone scaffold that combines traditional Chinese medicine with advanced biomaterials.
The researchers incorporated Dictamni Radicis Cortex, a traditional Chinese medicinal herb, into calcium silicate-based scaffolds manufactured using 3D printing technology.
The study demonstrated that these scaffolds not only provide structural support for bone regeneration but also regulate local inflammation, encouraging macrophages to shift toward a tissue-repairing state.
Importantly, these macrophages release extracellular vesicles enriched with miR-21, which act as molecular messengers to promote stem cell differentiation, blood vessel formation, and new bone growth.
In preclinical rabbit models of bone defects, the innovative scaffolds accelerated bone formation and improved tissue regeneration.
This breakthrough highlights the potential of integrating traditional Chinese medicine, 3D printing, and regenerative biotechnology, opening promising new directions for future bone reconstruction and precision regenerative therapies.
原文網址: https://link.springer.com/article/10.1186/s12951-026-04507-x
研究團隊｜Research Team
中文:何佳哲、徐端隄、林彥宏（共同第一作者）；林宗立、周德陽、謝明佑（共同通訊作者）及研究團隊。
英文：Chia-Che Ho, Tuan-Ti Hsu, and Yen-Hong Lin (Co-first Authors); Tsung-Li Lin, Der-Yang Cho, and Ming-You Shie (Corresponding Authors), and colleagues.
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