模擬肺部呼吸運動強化外泌體修復能力 中國醫大團隊開創肺纖維化治療新方向
日期：2026-10-30
資料來源：研究亮點｜陳建勳、周德陽、謝明佑等研究團隊
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模擬肺部呼吸運動強化外泌體修復能力 中國醫大團隊開創肺纖維化治療新方向
肺纖維化是一種肺部組織逐漸硬化、影響呼吸功能的疾病，現有藥物主要用於延緩病程，受損組織的修復仍面臨挑戰。中國醫藥大學附設醫院陳建勳、周德陽及謝明佑等研究團隊，結合生醫材料工程與再生醫學，開發模擬肺部呼吸運動的動態拉伸培養平台，提升間質幹細胞分泌之細胞外囊泡的治療潛力。
研究團隊利用特殊三維生物支架與規律拉伸刺激，活化幹細胞內的YAP訊號傳導，使細胞外囊泡中具有抗纖維化作用的miR-30含量增加。細胞與動物實驗顯示，經動態培養取得的囊泡可抑制纖維母細胞過度活化、減少膠原蛋白沉積，並調節巨噬細胞的發炎反應及改善受損細胞的粒線體功能。
這項研究證實，透過調控幹細胞生長的力學環境，可強化細胞外囊泡的組織修復功能，為肺纖維化的無細胞再生治療提供新策略。相關成果發表於國際期刊《Biomaterials》，未來仍須進一步驗證人體應用的安全性與療效。
Mimicking Breathing Motion Enhances Extracellular Vesicle Therapy for Pulmonary Fibrosis
Pulmonary fibrosis is a progressive disease characterized by excessive scarring and loss of lung elasticity, leading to impaired respiratory function. Although existing treatments can slow disease progression, restoring damaged lung tissue remains a major clinical challenge. A research team from China Medical University Hospital (CMUH), including Jian-Xun Chen, Der-Yang Cho, and Ming-You Shie, has developed an innovative biomimetic culture platform that harnesses mechanical stimulation to enhance the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (EVs).
By integrating three-dimensional auxetic scaffolds with rhythmic mechanical stretching that mimics natural breathing, the researchers activated YAP-mediated mechanotransduction in stem cells, promoting the enrichment of miR-30 within EVs. Experimental findings demonstrated that these engineered EVs suppressed fibroblast activation, reduced collagen deposition, modulated macrophage inflammatory responses, and restored mitochondrial homeostasis in damaged cells.
In a rat model of pulmonary fibrosis, the dynamically conditioned EVs improved lung tissue architecture and reduced fibrotic changes, demonstrating greater therapeutic potential than EVs obtained through conventional static culture.
Published in Biomaterials, this study highlights how engineering the mechanical environment of stem cells can enhance the regenerative properties of extracellular vesicles. The findings establish a promising foundation for developing cell-free therapeutic strategies for pulmonary fibrosis, while further safety and efficacy studies are required before clinical translation.
原文網址:https://www.sciencedirect.com/science/article/pii/S0142961226007295?via%3Dihub
研究團隊｜Research Team
中文：陳建勳、周德陽、謝明佑及共同研究團隊
英文：Jian-Xun Chen, Der-Yang Cho, Ming-You Shie, and colleagues
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