讓難以癒合的傷口重獲修復希望！中國醫大團隊開發新型再生醫學材料
日期：2026-10-22
資料來源：研究亮點｜謝明佑副教授
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讓難以癒合的傷口重獲修復希望！中國醫大團隊開發新型再生醫學材料
為什麼糖尿病患者的小傷口，有時卻久久無法癒合，甚至可能演變成嚴重的慢性傷口？
中國醫藥大學謝明佑副教授研究團隊，結合幹細胞技術與奈米生物科技，開發出一種具有促進組織修復潛力的新型膠原蛋白水凝膠，為糖尿病傷口治療帶來新方向。
研究團隊利用特殊的矽酸鈣材料刺激脂肪來源幹細胞，使其釋放更多具有修復功能的「細胞外囊泡」。這些微小囊泡就像細胞之間的訊息傳遞員，能協助調節發炎反應、促進細胞生長與血管新生。
研究人員進一步將囊泡包覆於膠原蛋白水凝膠中，讓修復物質能持續釋放。在糖尿病動物實驗中，這項創新材料展現降低發炎、促進膠原蛋白生成及加速傷口癒合的效果。
這項研究不僅展現生醫材料與再生醫學結合的創新潛力，也為未來糖尿病慢性傷口照護及新一代智慧型傷口敷料的開發，開啟值得期待的新方向。
New Hope for Chronic Wound Healing: CMU Researchers Develop Innovative Regenerative Biomaterial
Why do seemingly minor wounds in patients with diabetes sometimes take so long to heal, potentially developing into serious chronic wounds?
A research team led by Associate Professor Ming-You Shie of China Medical University (CMU) has combined stem cell technology and nanobiotechnology to develop an innovative collagen-based hydrogel with the potential to promote tissue regeneration, offering a promising new approach to diabetic wound treatment.
The researchers used a specialized calcium silicate material to stimulate adipose-derived mesenchymal stem cells, enhancing their release of extracellular vesicles (EVs) with tissue-repair properties. These tiny vesicles act as cellular messengers, helping regulate inflammation, promote cell growth, and stimulate the formation of new blood vessels.
The team further incorporated these vesicles into a collagen hydrogel, enabling their sustained release at the wound site. In diabetic animal models, this innovative biomaterial demonstrated promising effects in reducing inflammation, promoting collagen formation, and accelerating wound healing.
This breakthrough highlights the potential of integrating advanced biomaterials with regenerative medicine. It also opens new possibilities for developing next-generation wound dressings and improving the future treatment of chronic diabetic wounds.
原文網址: https://link.springer.com/article/10.1186/s12951-025-03097-4
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