為胰臟癌免疫治療找到新突破！中國醫大研究團隊提出雙重治療新策略
日期：2026-10-22
資料來源：研究亮點｜顏宏融教授
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為胰臟癌免疫治療找到新突破！中國醫大研究團隊提出雙重治療新策略
為什麼胰臟癌被視為最難治療的癌症之一，即使近年免疫治療快速發展，仍有許多患者無法獲得理想的治療效果？
中國醫藥大學顏宏融教授帶領研究團隊，在國際期刊《Advanced Science》發表重要研究成果，找到可能提升胰臟癌免疫治療效果的新方向。
研究發現，胰臟癌周圍的腫瘤微環境會抑制免疫細胞功能，使原本負責攻擊癌細胞的T細胞難以發揮作用。
研究團隊透過調控名為「UCP2」的蛋白質，改善T細胞的能量代謝，重新提升其抗癌能力；同時阻斷另一項與發炎及免疫調節有關的「IL-17」訊號，進一步減少腫瘤周圍的免疫抑制作用。
在多種胰臟癌動物模型中，這項雙重策略成功增強免疫反應，延長實驗動物存活時間。
這項研究不僅揭示胰臟癌逃避免疫攻擊的重要機制，也為未來發展更有效的癌症免疫治療，以及結合細胞代謝調控的精準醫療策略，開啟新的研究方向。
A New Breakthrough in Pancreatic Cancer Immunotherapy: CMU Researchers Develop a Promising Dual-Target Treatment Strategy
Why is pancreatic cancer considered one of the most difficult cancers to treat? Despite significant advances in immunotherapy, many patients with pancreatic cancer still struggle to achieve effective treatment outcomes.
A research team led by Professor Hung-Rong Yen of China Medical University (CMU) has published an important study in the prestigious international journal Advanced Science, identifying a promising new strategy to enhance immunotherapy against pancreatic cancer.
The researchers discovered that the tumor microenvironment surrounding pancreatic cancer cells can suppress immune responses, preventing T cells—the immune system's primary cancer-fighting cells—from functioning effectively.
By targeting a protein called UCP2, the research team demonstrated that T-cell energy metabolism could be reprogrammed to strengthen their cancer-fighting capabilities. Simultaneously, blocking IL-17, a signaling molecule involved in inflammation and immune regulation, helped reduce immune suppression within the tumor microenvironment.
In multiple pancreatic cancer animal models, this dual-target strategy significantly enhanced antitumor immune responses and prolonged survival.
These findings provide valuable insights into how pancreatic cancer evades immune defenses and open promising new directions for developing more effective cancer immunotherapies. By combining immune cell metabolic regulation with targeted immune modulation, this research represents an important step toward future precision cancer treatment strategies.
原文網址: https://pubmed.ncbi.nlm.nih.gov/41486584/
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