破解胃癌化療抗藥性！中國醫大洪明奇院士研究團隊發現提升治療效果的新機制
日期：2026-10-27
資料來源：研究亮點｜Yangwei Xu、葉再生、洪明奇、安利偉、張慶玲等研究團隊
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破解胃癌化療抗藥性！中國醫大洪明奇院士研究團隊發現提升治療效果的新機制
為什麼有些胃癌患者接受化學治療後，癌細胞仍然難以被消滅？如何讓原本效果有限的化療重新發揮作用，一直是癌症研究的重要課題。
中國醫藥大學洪明奇院士參與領導的國際研究團隊，在國際癌症研究期刊《Cancer Research》發表重要成果，發現細胞核內一種稱為「副斑點」（Paraspeckles）的微小結構，與胃癌細胞的化療敏感性密切相關。
研究發現，當WTX-S蛋白質與NONO蛋白質相互作用時，會形成特殊的細胞核內結構，進而破壞副斑點的穩定性，使胃癌細胞更容易受到化療藥物的影響。
更重要的是，研究團隊設計出一種模擬此作用的特殊胜肽WTXAP，在實驗中展現抑制腫瘤的潛力；搭配特定標靶藥物，也能進一步提高部分胃癌細胞對化療的敏感度。
這項突破揭開胃癌化療抗藥性的新調控機制，也為未來開發提升化療效果的精準治療策略，提供重要的科學依據。
Overcoming Chemotherapy Resistance in Gastric Cancer: CMU Researchers Discover a New Mechanism to Enhance Treatment Effectiveness
Why do some gastric cancer cells remain resistant to chemotherapy, even after treatment? Finding ways to make cancer cells more responsive to existing therapies remains a major challenge in cancer research.
An international collaborative research team co-led by Academician Mien-Chie Hung of China Medical University (CMU) has published significant findings in the prestigious journal Cancer Research, revealing a novel mechanism involving tiny structures inside the cell nucleus called paraspeckles, which play an important role in regulating gastric cancer's sensitivity to chemotherapy.
The researchers discovered that a protein known as WTX-S interacts with another protein called NONO, forming specialized nuclear structures that disrupt paraspeckle stability. This process makes gastric cancer cells more vulnerable to chemotherapy.
More importantly, the team developed a synthetic peptide called WTXAP that mimics this molecular interaction and demonstrated promising antitumor activity in preclinical experiments. Combining this approach with targeted drug treatment also showed potential to further enhance chemotherapy sensitivity in certain gastric cancer models.
This breakthrough advances our understanding of the molecular mechanisms underlying chemotherapy resistance and opens promising new avenues for developing precision treatment strategies that could improve the effectiveness of existing therapies for gastric cancer.
中文：
- 共同第一作者：Yangwei Xu、葉再生
- 共同通訊作者：洪明奇、安利偉、張慶玲
英文：
- Co-first Authors: Yangwei Xu, Zaisheng Ye
- Corresponding Authors: Mien-Chie Hung, Liwei An, Qingling Zhang
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